Can anyone tell me if these enemies have a game over? Serena Helen luci iris serena raven and and what are there in the city besides the club, 2 in the church and 1 with the girl in the trap, the same with a runner, a witch (who forces her to drink elixir), a dark witch (who gives money for a fetish), and a fairy. And just as interested in the fortress is it possible to defeat 10 enemies, and if so, how?
I'll reply to what I know towards HC 1 since I assume that game is the one you're coming from...
"And just as interested in the fortress is it possible to defeat 10 enemies, and if so, how?"
You will need to have an extremely strong MC, and at least 2 green and orange potions, very low or almost no fetish points, and 2 or less corruption points in your character, I recommend to have also the hammer equipped, this is something that while not mandatory, it will make passing through much easier, the only fetish you can get away with, is if you have high shemale since there are no shemales in the castle that I remember...
Serena, helen and luci if I'm not mistaken are all from HC 1 and all have either a bad ending or a small scene if you lose to them (kinda like what happens when you lose to Candy, you appear back in your camp), don't force yourself to try to get an extra scene, because there's only 1 game over scene per character, raven can't remember her...
Besides of the event of the club, you have the mouth or anal (or pass if your lust and fetishes are low) events, about the runner girl, I assume you mean the girl that challenges you to a sprint, it doesn't have a bad ending or something, it's just something to get a buff or increase your lust over the day (which will have consequences in case you lose a fight).
The dark witch also does not have a bad ending or scene, she's there to give you money in exchange for some of your exp...
TL;DR: Helen, Luci and Serena, no they are just lose and keep going characters (but your run will be screwed since you will have corruption points), dark witch and the rest are just events that you can gain something from...
Extra tip: You can get an idea of which enemies you will confront in the castle since it's a boss rush, some enemies are exclusive to the castle, while the bosses that you fought before to get the pieces of the map to access to it, will be there...